Can Notre Dame produce enough stops to unnerve Ohio State quarterback Kyle McCord as he plays in the toughest road environment of his career? The Fighting Irish counter with one of the nation's most-effective QB-RB duos in the form of Sam Hartman and Audric Estime. has 12 receptions for 286 yards and three touchdowns. Over the past two games, star receiver Marvin Harrison Jr. 9 Notre Dame: Notre Dame has been the more impressive of these two teams thus far, but the Buckeyes' passing game might be finding its groove. If he doesn't, the Hawkeyes could meet the same fate as Illinois. Iowa quarterback Cade McNamara will have to take better care of the football after throwing three interceptions in three games. The Nittany Lions will likely have to be better offensively if they are going to cover a spread this large against Iowa's stout defense. 7 Penn State -14: Penn State is playing a Big Ten West team for the second straight week after using a 5-0 turnover edge to beat Illinois 30-13 on Saturday. Colorado's defense has survived largely off its ability to force turnovers thus far and will have its hands full vs. But with two-way star Travis Hunter expected to be out with an injury for the Buffaloes, Oregon's high-flying offense will have a chance to make a statement of its own. 10 Oregon -19.5: This is a massive spread for a game between top-20 foes, especially considering Colorado already has a Week 1 road victory against a TCU team that was ranked No. This is Clemson's first time as a home underdog since 2016 and the Tigers will be eager to defend their home field. The Seminoles' sluggish play against the Eagles raises questions over whether they are ready to snap a seven-game losing streak to Clemson. 4 Florida State -2.5 at Clemson: Florida State found a way to survive and win 31-29 at upset-minded Boston College on Saturday. Odds via SportsLine consensus The big games Week 4 lines are out, so let's take a look at what oddsmakers are thinking as we look ahead. Rebels coach Lane Kiffin is looking to become the latest former Nick Saban assistant to take down the Crimson Tide. 15 Ole Miss in a showdown with major SEC West implications. That game is just the beginning of what could be the best week of the season's first month. It will be just the eighth all-time game between two of the sport's most storied programs after the Buckeyes defeated the Fighting Irish 21-10 last season in Columbus, Ohio. 9 Notre Dame for the first time since 1996 in a top-10 matchup for the second consecutive year. Headlining the schedule is a battle between heavyweight brands as No. Several games between ranked teams highlight the schedule as late September arrives with supremacy in the sport up for grabs. The first three weeks of college football season brought a few big matchups, but as Week 4 dawns, it's time to start separating the contenders from the pretenders in the major conferences and in the national championship picture.
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